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Pashon2001
Platinum Member


3575 Posts

Posted - 26 Dec 2009 :  7:50:06 PM  Show Profile  Send Pashon2001 an AOL message Bookmark this reply Add Pashon2001 to your friends list Send Pashon2001 a Private Message  Reply with Quote
Poor little Chadidja Medina, lets hope that her short life wasnt for nothing, and all stallions at least are tested. Then this never need happen again. As said before, carrier stock need not be culled, just intelligent choices on breeding made.


www.jarvastud.com http://hocon.webs.com/
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 29 Dec 2009 :  02:00:43 AM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote

All:

Beth Minnich passed the following on to me a few days ago and it readily explains how long the CA mutated defective allele has been in the arabian breed, how that has been deduced, and how the present research (based on Haplotype testing) at UC Davis works as explained by Leah Brault at their VGL laboratory. It also verifies the quality of the present marker scanning test. Please read through it all as it will answer many questions. Understanding how the scanning process works should clarify any doubts as to the accuracy of this testing method.

Also please note that the VGL lab at UC Davis archives their RNA samples collected and tested and will retest any "inconclusive" and advise the owners of the results. Their own laboratory has tested some 1100 horses as of 15 December 2009, coming from all over the world (not just the USA) and from all different bloodlines. The Lab doing the testing in the Netherlands sends their collected RNA to UC Davis for analysis confirmation. I do not know if the German (Hanover)and other laboratories are shipping to UC Davis as well. The disclosed results posted on the CA website (some 469 as of 22 Dec 2009) are a mere drop in the bucket compared to what has been tested or confirmed by parentage of an affected foal/horse.

The basis for haplotype tests is that a particular mutation has a common ancestor. This ancestor is the horse in which the original mutation first arose. There are genetic markers scattered throughout the genome, and this ancestor had particular alleles at the markers in the area of CA. So, for example, if the horse had the CA mutation arise on one chromosome, and he had alleles ABCDEFGH in that area, the genotype looked something like this (overly simplified version):

A--B--C--D--CA--E--F--G--H (chromosome 1)

a--b---c---d---N---e---f---g---h (chromosome 2)

These markers are all close together and the concept is that they will "travel" together as they are passed on. Therefore, when this horse passes on its CA allele, it will pass along ABCD(CA)EFGH, and when it passes on its normal allele, it will pass on abcd(N)efgh. Then, whenever offspring pass on the CA mutation, they too will pass on ABCD(CA)EFGH. The mutation moves with these associated markers through generations

When UC Davis first started looking at KNOWN carriers of CA (known based on production of affected foals,) and KNOWN CA affected foals (known based on diagnosis), they noticed that every affected foal was AA BB CC DD EE FF GG HH, and every carrier horse was A_ B_ C_ D_ E_ F_ G_ H_. Most of these early foals were pretty closely related, and so it wasn't a huge surprise - the assumption was that they were getting it from a great-grandsire or something. But, as more and more affected foals (based on diagnosis) were sent to the lab for testing, who didn't have common ancestors with the first group of foals until nine or ten generations back, they saw that ALL of these foals were also AA BB CC DD EE FF GG HH. That told the researchers that CA has a single ancestral source in the Arabian breed, one that is very, very old. These affected foals are of a variety of bloodlines, including Egyptian, so the CA mutation must predate the division of these "nationality/geographic" subgroups, since they all carry the same marker alleles.

When testing is done, the lab is looking for these alleles--ABCDEFGH. I believe they have found about 40 markers that travel with CA and they test for 15 (so the A-H example is simplified). Although it isn't possible to determine an overall % accuracy for the test, the research shows a very high degree of success. Theoretically, there could be another source of CA in the Arabian breed (meaning a different haplotype would be involved) or there is a very slight possibility of the halplotype they are testing for exisitng in a "normal form" in some horses. I'm not aware of any of these theories playing out as reality, but yes, theoretically it is possible. However, something we DO know is that when two carriers are bred together, there is a 25% probability of having an affected foal - so which odds do you want to go with?

In terms of test results - ALL of the confirmed affected foals tested so far have had two copies of the CA haplotype. They have NOT yet seen a confirmed affected foal that did not carry two copies of these markers. So, the presence of these markers is certainly very indicative of CA. Occasionally a horse is tested with an "odd" haplotype...perhaps it has ABCD, but not EFGH. In these cases, the result is listed as "undetermined". As they continue to narrow the CA region down further and further, some of these "undetermined" cases are being resolved and it is becoming very rare among the rare to get an "undetermined" result now.

In the end, Arabian breeders need to decide whether the very small chance of error is worth it when making breeding decisions. Also of note, people who are testing now (directly through UC Davis, not necessarily through one of the European labs) will NOT need to send another sample when the direct test becomes available. The lab will automatically re-test and let owners know if they obtained a different result.

The indirect CA test is a very valuable tool for breeders, especially for those working with known CA lines. The choice is there to use or not to use....with the primary goal being not to produce affected foals. IMO, that is where the focus should be....no more affected foals.


The use of crossbreeding with untested arabians can and will introduce CA into other breeds. Some non arabian breed registries already have recognized this danger and are requiring that any new arabian infusions are pretested for CA status, prior to acceptance for breeding.

LisaC


Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 29 Dec 2009 :  04:14:12 AM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
Originally posted by SiriusThanks for your reply, but I'm still not happy. I think that testing now could actually lead to a worsening of the situation if people are overconfident about their results.

Why should people be over confident about their results Dom?
A N/N CLEAR horse can not have the defective CA allele.
A N/CA CARRIER horse does carry one copy of the defective CA allele.
A CA/CA AFFECTED horse/foal is obviously affected and its parents both will be CARRIERS. When euthanized its affected status is confirmed by histopathological diagnosis.


My problem is in your assertion that the markers accompany 100% of defective alleles. I would suggest that this is over confident. I am sure that it is a confident statement in that 100% of unambiguously diagnosed affected CA/CA so far tested have been reported to have the markers.

Please read post on Haplotype testing of well over one thousand samples.

I presume that UC Davis have been breeding and testing a herd of N/CA and CA/CA in-house rather than just testing samples from the national herd. However, it is vital to identify all of the carriers and only the carriers in this, and my worry is that those who test now will believe the results are definitive.

Your presumption is incorrect. UC Davis does not have a test herd. Nor is their testing limited to USA arabians only. They receive samples for testing from all countries and all bloodlines. Do not confuse the VGL lab at UC Davis with the VetGen Laboratory which handles SCID testing.

I am quite concerned that we now have people posting "clear" results with the implied confidence that the horses are N/N.

They are posting N/N "Clear" results with confidence because their horses DO NOT have the haplotype for the defective mutated CA allele. If it is not there Dom , it simply is not there.


Undoubtedly they have tested for all of the right reasons, and have done absolutely everything available to avoid breeding CA/CA foals, but there are three big questions for me:

1/ With rare bloodlines said to be carrying the CA allele, will owners of quality horses that have CA/N indications now terminate those lines? A great shame if so, as our experience of SCID, and of PRA, CNM, EIC and narcolepsy in labradors, shows that they can be completely eradicated in two generations at the worst;

There is NO reason for quality breeding stock that are N/CA, CARRIERS, to terminate breeding forward their bloodlines. N/CA stallions require outside mares to be tested; N/CA mares are used to breed to N/N Clear stallions. If two tested carriers are bred together , both mare and stallion owners are aware of the risks. Please study the posted Status List at the CA website (not the very outdated one here on this thread)and you will see tested clear foals resulting from 2 carriers. It can happen.

2/ Will those people retest their horses if/when the allele is identified and a direct test becomes available? This is my main concern, as I was about to spend around £1000 which I cannot afford to do and then redo.

Why should they? The present testng is a reliable tool for making breeding selections in order to avoid producing affected foals.
If you yourself are uncomfortable about the marker scanning test and do not fully understand about Haplotype testing, then dont spend your money.


3/ Have any clears thrown positive results for the markers, or is this possible? Indeed, is there a way of knowing the answer to this, as carriers are asymptomatic? If the test mislabels a rare-lined clear as a carrier, that could terminate what we are all trying to preserve. Only a very large test herd can answer this question, and then over several generations.

Your question about clears being able to throw positive results for markers tells me that there are still some fuzzy borders around your own knowledge of genetics. It is NOT possibe for a clear N/N horse to have carrier markers in the genome makeup. That is why they are called "Clear or Normal". Yes. Carriers are asymptomatic as you say. It is more correct to say that Carriers do not have or express any clinical signs. (In medical language only those who can explain what symptoms they have,can use the terminology of symptoms. All else are clinical signs.) As stated UC Davis no longer has a test herd and I dont know where you got that idea from. Back in 1985 the late Ann T. Bowling delt with a test herd of 40 head which consisted of carriers and affecteds collected from different bloodlnes and from across the United States. From that herd she established the recessive mode of inheritance. Post mortum necropsies proved the atrophy of the Purkinje cells, the definitive diagnosis of CA.

If the current test eventually proves not to be 99.99% reliable in picking up the defective allele in the wider international herd, the premature publication of "clear" results could actually have an enormously damaging Affect(sic).

The current test HAS BEEN proven to be reliable in the "International Herd" (again please read Haplotype Post and review the Public Status List.) To call it a "premature" publication of results may be reflective of your own approach, but it is obviously not reflective of the many well known and responcible breeders who have disclosed publically their "clears", "carriers" and "affecteds". In furthering your own research, I highly recommend that you look up the pedigrees at www.allbreed.com and/or the AHA Datasource. Links are provided onsite. This will give a better idea of the scope of bloodlines and the variation of countries involved.

If our stallions test N/N, then with our plans they will be breeding prolifically, and the publication of their results will probably increase the number of mares visiting them, helping to recoup the testing cost.

Hopefully that would be correct.

There are a number of cases of carrier labrador retrievers of magnificent working achievement who have had truely monsterous numbers of puppies, e.g. XXX who sired over 8000 and was certainly a carrier. Their owners all used the best knowledge available at the time to produce the best quality sire dogs, and the parallel is chilling.

In the arabian horse world a similar situation has occurred on several occassions: Muscat 1971-1996 , sire of significance had over 1000 get and 5524 grandget and his bloodlines are still sought out for their superlative action in spite of being an acknowledged carrier. Magnum Psyche, sire of 1197 and 1637 grandget(a large number for a living sire),is another prolifically used confirmed carrier. A good horse is a good horse and a top quality breeding sire is not going to be limited by a CA Carrier status.[

u]Let me add that I am a huge believer in testing[/u]. All of our herd are SCID tested, and the results are publicly available on our website especially the late Hanson's SCID carrier status. We have been successfully breeding out the large number of genetic diseases that afflict working labradors, and have the most tested (and most multiply completely N/N clear) working breeding pack in the UK. I went onto the Van Haeringen website specifically to find the test order form for CA, which is where I found the info I originally quoted.

Yes . I am aware of the Van Haeringen website as I was the one who first started to post it on the discussion groups. As the testing process orignated at UC Davis I suggest reading their website information and contacting Dr. Penedo or her assistant Leah Brault directly. This may assuage some of your doubts as to the accuracy of the present testing, if the Haplotype post has not.

We will test, publish, and publicise as soon as we are confident that the test available is definitive. In the meanime, we are certainly more aware of the possibility of CA and will be vigilant.

Dom
Seren Arabians

p.s. I want to be wrong on this one!



Breeding Farms with a closed genetic pool which have started off with CA Clear foundation stock will not be likely to see an affected foal within their own program. Even so it is a good idea to test the primary stallion and the foundation mares to be sure of their status. If all are N/N , Clear, then subsequent foals derived from these breeding combinations will not have to be tested as they will be clear as their parents are clear.


Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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cookie
Silver Member


United Kingdom
331 Posts

Posted - 29 Dec 2009 :  10:37:18 AM  Show Profile  Send cookie an AOL message Bookmark this reply Add cookie to your friends list Send cookie a Private Message  Reply with Quote
Brilliant !!!
It is good to have this explained,should go further to convince the owners of stock to test ALL their horses who are to be used for breeding.
jane

j.e holloway
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Sirius
Bronze Member

England
102 Posts

Posted - 29 Dec 2009 :  11:38:54 PM  Show Profile Bookmark this reply Add Sirius to your friends list Send Sirius a Private Message  Reply with Quote
Thanks, Lisa,

This is the first explanation of the haplotype link to appear on AL so far. The labs and UC Davis seem to be relying on you to provide the information.

I have replied on the other thread already, and here it is again:

"Thanks for posting this, Lisa. It's much the clearest explanation so far of the test. The labs haven't answered any of the questions put to them.

I must "admit" that I tested the mature stallions some weeks ago, and am still waiting for the results. I'm waiting for the definitive test before I test any of the boys who are not yet mature, unless they mature in the meantime.

Once the definitive test is available, I will test the whole herd including the geldings, and alert any of the owners of our youngstock if there are any suspicious results at all.



There's an interesting assumption about the relative responsiblities of mare and stallion owners running through all of this, but that belongs to another thread!

Dom
"

Without being a pedant (which i'm not), there's one point that needs to be answered in your reply to me above:

"I am quite concerned that we now have people posting "clear" results with the implied confidence that the horses are N/N.
"They are posting N/N "Clear" results with confidence because their horses DO NOT have the haplotype for the defective mutated CA allele. If it is not there Dom , it simply is not there."
Yes, but the info provided to date by the testing labs casts doubt on that vital point: they don't bother to link the haplotype with the mutated CA allele, and just expect us to accept it gratefully without understanding it...

Dom


Edited by - Sirius on 30 Dec 2009 12:01:48 AM
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 30 Dec 2009 :  1:52:58 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
Dom,

I am having trouble following your line of reasoning here:
You write---Yes, but the info provided to date by the testing labs casts doubt on that vital point: they don't bother to link the haplotype with the mutated CA allele, and just expect us to accept it gratefully without understanding it...

The UC Davis CA website has it spelled out pretty clear or so it seems to me:

The genetic basis of CA is currently under investigation at the Veterinary Genetics Laboratory. While the specific mutation that causes CA is not yet known, we have identified a group of genetic markers adjacent to gene that can be used as a surrogate test (or indirect test) for CA. When genetic markers lie close to a gene of interest, they often are inherited along with the trait. The CA test looks for a specific set of alleles that are co-inherited with CA which can be used as a diagnostic tool to identify affected foals and also animals that are potential carriers of the disease. Breeders who wish to test their horses before breeding may use the CA test in order to avoid breeding two suspected carriers together.

I personally have explained about the markers time and time again on many different discussion boards.
In short: where the recognized markers are will be also the CA defective mutated allele or it will not. If one copy is included with the markers the horse will be a carrier. If two copies are included then the horse will be affected. If no copies are included with the markers then the horse will be normal or clear.

There always has to be a transfer of two chromosones. The CA defective mutated allele travels with the markers. There will be a set of similar markers on each chromosone. The 100% results of double markers in the disected brain samples of the affected foals/horses tested to date designates the marker scanning test as very robust.
As a physicist you know that there are no concretes in the scientific world so what UC Davis has found to date is very strong as far as accuracy is concerned.

I know your initial information came from the translated site of the Van Haeringen Lab in Holland. Remember that UC Davis is the main researcher on CA, worked on it over 20 years ago and reopened research in 2005 under the guidance of Dr,. Cecilia Penedo who had studied with the late Anne Bowling. I suggest keeping in touch with their research for the latest up dates.

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/

Edited by - szedlisa on 30 Dec 2009 1:58:26 PM
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Sirius
Bronze Member

England
102 Posts

Posted - 30 Dec 2009 :  4:23:38 PM  Show Profile Bookmark this reply Add Sirius to your friends list Send Sirius a Private Message  Reply with Quote
Yes, Lisa, I'm now of the opinion that I haven't wasted the fee for the tests I have submitted. I'm also waiting for replies from UC Davis which may convince me to start the testing of the other 15 as well.

I note that the VH site is still carrying the same doubt-producing information about the test, and their terms and conditions section 7 gives them the usual walk-away from the consequences if the test had turned out to be based on wishful thinking.

I make no apologies for asking the questions and raising my doubts. The resistance I have encountered in bringing other dog breeders on board as far as genetic testing is concerned has taught me that people need the clearest explanation available.

Once I am completely happy with the reliability of the testing, we will make the same offer to other breeders as we already do with the dogs: as well as offering clear stallions to carrier mare owners, we will also offer carrier stallion owners the opportunity to bring their stallions here to our clear mares to rescue their lines. (Note the optimistic assumption here!)

Dom


ADMIN: this is not an advertisement!
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 08 Jan 2010 :  03:05:53 AM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote

The CA website has moved to a new server with a broader band so we now have faster downloading :

http://www.cerebellar-abiotrophy.org/

We are also pleased to say that over 500 entries have been made on the CA Status List.
Including a first time result from a deceased stallion by using frozen semen.
Our applause to Rojo Arabians for their support and efforts with VERSACE !!
And his dam!

Check it out.

Register to get the latest updates.

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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leighann
Gold Member

Scotland
512 Posts

Posted - 12 Jan 2010 :  8:36:01 PM  Show Profile Bookmark this reply Add leighann to your friends list Send leighann a Private Message  Reply with Quote
MONESCOCIA (Ajman Moniscione x Estoniah) CA & SCID CLEAR .

Leigh-Ann
www.carradalearabians.co.uk

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SueB
Platinum Member


United Kingdom
3218 Posts

Posted - 01 Feb 2010 :  11:34:24 PM  Show Profile  Send SueB an AOL message Bookmark this reply Add SueB to your friends list Send SueB a Private Message  Reply with Quote


Mare.

G.Fantastica (IBN Estopa x Fanatica) Tested UC Davis CA clear.
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Sirius
Bronze Member

England
102 Posts

Posted - 02 Feb 2010 :  6:47:44 PM  Show Profile Bookmark this reply Add Sirius to your friends list Send Sirius a Private Message  Reply with Quote
This morning we received the first 4 results. The original set of samples didn't arrive in Holland, hence the forever wait...

UC Davis emailed on Thursday that they had received the samples, and the results arrived at 0200 GMT Tuesday (or about 1800 local time on Monday in California. That's faster than their most optimistic published turnround of 5 working days.

Winged Saint: SCID clear and now CA clear
Halal: SCID carrier and now CA clear
Seren Hanau: SCID clear and now CA clear
seren Hanag: SCID clear and now CA clear

Dom
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Sirius
Bronze Member

England
102 Posts

Posted - 03 Feb 2010 :  9:50:20 PM  Show Profile Bookmark this reply Add Sirius to your friends list Send Sirius a Private Message  Reply with Quote
Just a little request:

Yesterday (2/2/09) I posted our first 4 results on one of the CA threads, before submitting them to the CA website.

Today I checked the international list. Someone had posted our results there before my own submission (described as "on arabianlines.com" in the header - which means how the information was gathered).

Now that's not a problem, except that the person who posted the results got them wrong.

One of the boys is a SCID carrier, incorrectly copied by whoever as clear - see my postings on the CA threads. I would hate anyone to think we were trying to cover up a carrier status, and I hope that I have corrected the error (resubmitted to the CA site and I hope they won't just look at it and say: "weve already got him...")

I suggest that people don't rush in to submit other peoples' results. We don't need an assumption that the owners will try to deceive us: that's paranoia. If you do submit under a sort of freedom of information flag, GET IT RIGHT.

Dom
Seren Arabians
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 03 Feb 2010 :  10:43:03 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
Dom,

I have emailed Trina our webmaster and my sincerst apologies for the mistake. As part of the CA website team , as stated on the Public List:

Owners or agents of the following horses have disclosed their results publicly on websites, public forums, equine journals or given permission privately. Any information unintentionally or otherwise wrongly posted will be removed with-in 48 hours upon request of owner or authorized agent.


Our team consists of myself , Trina the webmaster (and owner of an affected foal) and Gideon who most generously donated the website domain for us. Trina is on the far side of the US so the time difference sometimes is a handicap but I assure you she will correct it as soon as possible.

Again my sincerest apologies for the mistake of typying SCID clear instead of a SCID carrier

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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JuliaB
Bronze Member


England
89 Posts

Posted - 04 Feb 2010 :  09:22:04 AM  Show Profile Bookmark this reply Add JuliaB to your friends list Send JuliaB a Private Message  Reply with Quote
Just had the CA result back on my daughter, Olivia's, 2 year old colt Phantom (Azteq x Pjatakova) which is clear (N/N). To say we are pleased is an understatement.

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szedlisa
Bronze Member


Spain
124 Posts

Posted - 04 Feb 2010 :  2:12:00 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
JuliaB,

Congratulations ! That is great news. Be sure to share it and submit your test results to the CA Website:
http://www.cerebellar-abiotrophy.org/

Lisa

Originally posted by JuliaB

Just had the CA result back on my daughter, Olivia's, 2 year old colt Phantom (Azteq x Pjatakova) which is clear (N/N). To say we are pleased is an understatement.

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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cookie
Silver Member


United Kingdom
331 Posts

Posted - 09 Feb 2010 :  11:42:24 PM  Show Profile  Send cookie an AOL message Bookmark this reply Add cookie to your friends list Send cookie a Private Message  Reply with Quote
I am very pleased to be able to say that Pianist(Gazal al Shaqab x HS Pelagrina) has just tested N/N clear for CA.Still awaiting scid results.
Just had his Scid result back.Scid clear.

j.e holloway

Edited by - cookie on 25 Feb 2010 12:42:43 AM
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pintoarabian
Gold Member

Scotland
1242 Posts

Posted - 02 Mar 2010 :  9:05:17 PM  Show Profile Bookmark this reply Add pintoarabian to your friends list Send pintoarabian a Private Message  Reply with Quote
CA results for our gang in today:

Picasso Kossack (Kubinec x Popova) CA clear.SCID clear.
Rodania Karisma (Farrukh x Kadidja) CA Clear.SCID test pending.
Prima Ballerina (Thee Onyx x LC Special Treat)CA Clear.SCID clear.
Malibu Surfbreaker (Kennox Zalsun x Mistral Whisper)CA Clear.SCID clear.
TP Starbuck (Black Tie x TP Mystic Fire) CA Clear.SCID clear.
Incandescent Flame (TP Starbuck x Malibu Surfbreaker CA Clear.SCID clear (both parents tested clear).
AKA Starbuck's Champagne Star (TP Starbuck x Malibu Surfbreaker) CA Clear.SCID clear (both parents tested clear).
Roundhills Crystal King (Moonshine Vision x Shulay Coral) CA clear. SCID clear.
It's Showtyme (Infiniti Z x Hunter's Moon) CA clear. SCID clear.

Having a problem posting results for the part breds on the CA site as their colours aren't recognised and colour is a required field.

http://www.performancearabians.com
http://performancearabians.blogspot.com/
https://www.facebook.com/PerformanceArabians
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Avonbrook
Silver Member

287 Posts

Posted - 03 Mar 2010 :  8:50:07 PM  Show Profile Bookmark this reply Add Avonbrook to your friends list Send Avonbrook a Private Message  Reply with Quote
Good to see, Pinto If the CA site is going to be a complete database there will be quite a few people Worldwide affected by the difficulties in posting colours so I guess they will want to change that.

Given that he is chestnut, even I managed to navigate the site to post that Marcus Aurelius is CA in addition to SCID clear .

Rowena



www.avonbrookstud.co.uk
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 15 Mar 2010 :  12:30:33 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
There have been some changes at the CA website
www.cerebellar-abiotrophy.org

Due to the amount of entries and space available on even this excellent band width, the CA Status List has been redesigned into two sections:

MAIN LIST with all entries posted in the order received: Horse Name + Identification + Status
CARRIER /AFFECTED LIST in alphabetical order with Horse Name + Identification + Status.

SEARCH OPTIONS remain the same on both pages:
- Use search box provided at top of each page for a page search.
- Right click on entry without number and do a Google Search. This usually brings up website / farm name / owner or breeder info.

Please note the following important additions:
ADDITTIONAL DEFAULT DERIVED CA STATUS IN ACCORDANCE WITH THE BREEDING CHART:
Only owners of horses have the option to submit and publish two default CA derivatives under their own responsibility:
- "CA: Clear by parentage" - for a foal of which both parents are tested CA N/N CLEAR
- "CA: CARRIER by default (I)" - for a parent of a CA: CA/CA AFFECTED foal
- "CA: CARRIER by default (II)" - for a parent of a CA: N/CA CARRIER foal of which the other parent is CA: N/N CLEAR

The CA Marker Scanning Test was officially launched in September 2008. Horses tested by this method and those horses clinically diagnosed with a necropsy prior to this date are designated by the symbols N/N Clear, N/CA CARRIER or CA/CA AFFECTED where applicable. Horses which were vet diagnosed based on clinical signs but not clinically diagnosed with a post mortum microscopic study (Histopathic) are termed simply AFFECTED.

Thank you,
Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/

Edited by - szedlisa on 15 Mar 2010 3:48:28 PM
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szedlisa
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Spain
124 Posts

Posted - 09 Apr 2010 :  3:42:30 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote

http://www.laboklin.co.uk/laboklin/showGen...?testID=8001HGD


ALL:

I have heard from Dr, Penedo and LABOKLIN (UK) is also working in conjuction with UC Davis to do the CA testing. Same link as above and use their contact email to get more information.

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 18 Apr 2010 :  04:02:05 AM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote

Now on the heels of the Swiss Registry accepting compulsorary testing for CA , we
have Saturday“s results in on:

VZAP (German Arabian Registry)

German to English translation
Results of the Annual General Meeting:

All breeding horses, whether new or old, mare or stallion must be tested.
Breeding animals that are re-recorded must be tested immediately, the "old" have a transitional measure until 31.12.2011.

There were no abstentions - so there were all members present 100% for the tests.

The already made tests are accepted in full.


Hopefully this will give other registries an incentive to do the same.!

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 28 Sep 2010 :  11:43:25 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
I am delighted to see that the AUSTRALIAN REGISTRY IS LEADING THE WAY IN ARABIAN HORSE GENETIC DISEASES !!!!!!!!!!!!!!!!

http://www.arabiansdownunder.com.au/Hot_Topics.php

The above is based on the September Bulletin of the AHSA:
http://www.ahsa.asn.au/downloads/BulletinSept10.pdf

1st January 2011 is the cut off date.
- No imported breeding stock will be allowed to be registered unless DNA results of tests for SCID, CA and LFS are presented to the AHSA.
- No imported semen will be allowed for use unless AHSA has receipt of DNA tests for SCID, CA and LFS.
- The Board is also actively investigating the testing of ALL nominated stallions for SCID, CA, LFS and GPA (as tests become available) with the intention of publishing the results on the online Stud Book.

The CA WEB has this information also on the Latest News Page:
http://www.cerebellar-abiotrophy.org/index.php?option=com_content&view=category&layout=blog&id=1&Itemid=28

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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szedlisa
Bronze Member


Spain
124 Posts

Posted - 23 Oct 2010 :  4:10:40 PM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
The latest statistics are in




This week we received the latest statistics from UC Davis. Nothing changed much from the previous information, which means that the carrier percentage remains the same, just under 20%.

Disclosures of carriers and clears on the CA website also stayed steady at ~ 12% and 86% respectively. These numbers vary strongly from those of UC Davis, but logically owners are swifter to disclose a clear rather than a carrier.

For the complete overview go to the statistics page.

http://www.cerebellar-abiotrophy.org/index.php?option=com_content&view=article&id=19&Itemid=27

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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barbara.gregory
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United Kingdom
4531 Posts

Posted - 01 Dec 2010 :  10:07:14 PM  Show Profile Bookmark this reply Add barbara.gregory to your friends list Send barbara.gregory a Private Message  Reply with Quote
I have just been rereading this thread and I noticed that an affected foal had "a protracted birth and took a long time to stand. it also stood at the back end first rather than at the front". Is this usual in CA affected foals and is standing with the rear end first indicative of CA in the newborn as I understood from the literature that CA foals were normal for weeks/months after birth and only developed symptoms as the purkinge cells died off rather than developed?

Barbara

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szedlisa
Bronze Member


Spain
124 Posts

Posted - 02 Dec 2010 :  02:46:37 AM  Show Profile Bookmark this reply Add szedlisa to your friends list Send szedlisa a Private Message  Reply with Quote
Barabara,

As we all know too well, new born foals have a pretty wobbly time of it when trying to get to their feet. I have seen perfectly normal foals use their muzzle to support themselves as they try to stand.

A CA Affected foal is going to have a difficult time trying not to run into things once it is on its legs. The most noticable clinical sign of CA is the head tremors.

As for the protracted birth , that is more of a problem of the mare“s, not the foal“s condition. The mare is the one trying to push the foal out. The foal is just going along with the whole proceedure.

Lisa

Spanish Arabians Photos
http://www.flickr.com/photos/szedlisa/collections/72157600851198212/
Cerebellar Abiotrophy (CA) Info:
http://www.cerebellar-abiotrophy.org/
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